Thermo Fisher Scientific Phospho-SMAD4 (Thr277) Polyclonal Antibody
Phospho-SMAD4 (Thr277) 폴리클로날 항체로 인간 및 생쥐 시료에 반응. Western blot에 최적화된 제품. KLH 결합 합성 인산화 펩타이드로 면역화. Protein A 및 항원 친화 크로마토그래피로 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA512695
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T277 of human SMAD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2193350 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
Smad4 is encoded by the Smad4 gene located on chromosome 18 in humans. Also known as Smad family member 4, Sma- and Mad-related protein 4, or Mothers against decapentaplegic homolog 4.
Smad4 contains N-terminal MH1 and C-terminal MH2 globular domains involved in DNA binding and protein interactions.
Binding of TGF-beta superfamily ligands (including TGF-beta and BMP) to their receptor allows phosphorylation of Smad1, 2, 3, 5, and 8 (R-Smads), which then form heterotrimers with Smad4 (co-Smad) and translocate to the nucleus.
Smad4 functions as a tumor suppressor, regulating genes such as Cyclin D1 (downregulation) and collagen (upregulation) to inhibit cell proliferation. Dephosphorylation controls nuclear export and nucleocytoplasmic dynamics of Smads.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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