Thermo Fisher Scientific Phospho-SRC (Tyr215) Polyclonal Antibody
SRC 단백질의 Tyr215 인산화 부위를 인식하는 Rabbit Polyclonal 항체로, Western blot에 적합합니다. 인간에 반응하며, 단백질 A 및 항원 친화 크로마토그래피로 정제되었습니다. 세포 신호전달 및 암 연구에 활용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y215 of human SRC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2196027 |
Product Specific Information
This antibody is predicted to react with chicken, mouse, rat, Xenopus, and zebrafish based on sequence homology.
Target Information
SRC is a cytoplasmic tyrosine kinase and proto-oncogene involved in the regulation of embryonic development and cell growth. It regulates growth and differentiation of eukaryotic cells and associates with cytoplasmic regions of various cell surface receptors to facilitate signal transduction. SRC also participates in cytoskeletal organization, cell cycle regulation, and apoptosis.
In humans, the SRC gene is located on chromosome 20. Its activity is regulated by phosphorylation at two tyrosine residues (Tyr416 and Tyr527), which have opposing effects: phosphorylation at Tyr416 activates, while phosphorylation at Tyr527 inhibits enzyme activity. Mutations in SRC may contribute to malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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