Thermo Fisher Scientific Phospho-CREB (Ser129) Polyclonal Antibody
CREB 단백질의 Ser129 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 고순도(>95%) 항체로 인간, 마우스, 랫트 반응성. 연구용으로 신경전달, 신호전달, 기억 관련 CREB 활성 연구에 적합.
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- PA536843
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human CREB around the phosphorylation site of Serine 129 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long term, store at –20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553772 |
Product Specific Information
- Detects endogenous CREB protein at a molecular weight of 38 kDa.
- Purity >95% by SDS-PAGE.
Target Information
CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to extracellular signals such as neurotransmitters, hormones, membrane depolarization, and growth/neurotrophic factors.
Activation of CREB depends on phosphorylation at serine 133. Phosphorylation occurs via p44/42 MAP kinase, p90RSK, p38 MAP kinase, and MSK1. While CREB binds DNA regardless of phosphorylation state, only the phosphorylated form functions as a transcription factor.
CREB binding protein (CBP), a transcriptional coactivator, interacts with CREB near serine 133. CREB participates in cellular processes including circadian rhythm regulation, adipocyte differentiation, and learning and memory.
In humans, the CREB gene is located on chromosome 2q. Dysfunction of CREB is associated with Alzheimer’s disease, histiocytoma, and soft tissue melanoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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