Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser345) Polyclonal Antibody
Phospho-Progesterone Receptor (Ser345) 항체로, 인산화된 PR 단백질의 Ser345 부위에 특이적으로 결합합니다. Western blot과 Immunocytochemistry에 적합하며, 사람, 마우스, 원숭이, 랫트 시료에 반응합니다. 고순도 정제 및 안정한 PBS/glycerol buffer에 보관됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PGR (Accession P06401), corresponding to amino acid residues around phosphorylated Ser345. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2903210 |
Product Specific Information
This antibody detects endogenous levels of Progesterone Receptor only when phosphorylated at Ser345.
Target Information
The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), resulting from alternative translation initiation sites.
- PR-B: Transcriptionally active form responsible for endometrial maintenance, pregnancy maintenance, and inhibition of ovulation.
- PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.
In its inactive state, the progesterone receptor forms a multiprotein complex including heat shock proteins and immunophilins. Upon hormone binding, conformational changes allow dimerization and binding to progesterone response elements (PRE), leading to transcription activation.
A null mutation in the PGR gene can result in reproductive abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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