Thermo Fisher Scientific Phospho-Progesterone Receptor (Ser345) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Progesterone Receptor only when phosphorylated at Ser345.

Target Information

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy.
PR exists as two isoforms: a 94 kDa protein (Form A) and a 120 kDa protein (Form B), resulting from alternative translation initiation sites.

• PR-B: Transcriptionally active form responsible for endometrial maintenance, pregnancy maintenance, and inhibition of ovulation.
• PR-A: Identical to PR-B except for a 165 amino acid deletion at the N-terminus, exposing a 140 amino acid inhibitory domain that represses steroid hormone transcriptional activity.

In its inactive state, the progesterone receptor forms a multiprotein complex including heat shock proteins and immunophilins. Upon hormone binding, conformational changes allow dimerization and binding to progesterone response elements (PRE), leading to transcription activation.
A null mutation in the PGR gene can result in reproductive abnormalities.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.