Thermo Fisher Scientific Phospho-NACA (Thr159) Polyclonal Antibody
Phospho-NACA (Thr159) 폴리클로날 항체로 인간, 마우스, 랫트에서 반응. Western blot 및 IHC(P) 실험에 적합하며, 인산화된 Thr159 부위의 NACA를 특이적으로 검출. 고순도 정제 및 안정적 PBS/glycerol 저장 포뮬러 제공.
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- PA5118705
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human NACA (Accession Q13765), corresponding to amino acid residues around phosphorylated Thr159 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903205 |
Product Specific Information
Antibody detects endogenous levels of NACA only when phosphorylated at Thr159.
Target Information
NACA prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). It binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER.
NACA also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites), and may act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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