Thermo Fisher Scientific Phospho-PDX1 (Ser66) Polyclonal Antibody
PDX1의 Ser66 인산화 상태를 특이적으로 검출하는 rabbit polyclonal antibody입니다. Western blot, IHC, ICC/IF 등에 사용 가능하며, 인슐린 및 췌장 발달 관련 연구에 적합합니다. 고순도 정제 및 안정적 액상 형태로 제공됩니다.
- 카탈로그번호
- PA5118709
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human PDX1 (Accession P52945), corresponding to amino acid residues around phosphorylated Ser66 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903209 |
Product Specific Information
This antibody detects endogenous levels of PDX1 only when phosphorylated at Ser66.
Target Information
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2.
It is a nuclear protein involved in early pancreatic development and plays a major role in glucose-dependent regulation of insulin gene expression.
Defects in this gene can cause pancreatic agenesis, leading to early-onset insulin-dependent diabetes mellitus (NIDDM) and maturity-onset diabetes of the young type 4 (MODY4).
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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