Thermo Fisher Scientific ROR2 Monoclonal Antibody (OTI2G1), TrueMAB

Applications and Tested Dilutions

Product Specifications

Target Information

ROR2 (receptor tyrosine kinase-like orphan receptor 2) is a type I transmembrane protein belonging to the ROR subfamily of cell surface receptors. It is involved in early chondrocyte formation, cartilage, and growth plate development. ROR2 is highly expressed during early embryonic development, with expression decreasing significantly by day 16 and remaining low in adult tissues.

Defects in ROR2 are associated with:

• Brachydactyly type B1 (BDB1): An autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. Both fingers and toes are affected, with deformities in thumbs and big toes.
• Recessive Robinow syndrome (RRS): An autosomal disorder causing skeletal dysplasia, limb bone shortening, spinal defects, brachydactyly, and facial dysmorphia.

The protein contains:

• 1 Frizzled (FZ) domain
• 1 Immunoglobulin-like C2-type domain
• 1 Kringle domain

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.