Thermo Fisher Scientific KIM-1 Recombinant Rat Monoclonal Antibody (3B3)
쥐 유래 KIM-1 단백질을 인식하는 Thermo Fisher Scientific의 재조합 Rat Monoclonal Antibody (Clone 3B3). IHC, ICC/IF, Flow Cytometry 등 다양한 면역실험에 적합하며, Protein A로 정제된 액상 형태. 장기보관 시 -20°C에서 냉동 보관 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific KIM-1 Recombinant Rat Monoclonal Antibody (3B3)
Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Functional Assay | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 3B3 |
| Immunogen | Female Lewis strain rats immunised with mouse TIM-Ig in CFA, followed by boosting with mouse TIM-1-Ig in PBS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_3074583 |
Product Specific Information
Specificity: This antibody is specific for murine TIM-1, a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family.
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a cellular receptor or co-receptor for several viruses, including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus.
Viral binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms within the human CD365 gene (HAVCR1) are associated with susceptibility and disease severity.
CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells. It is highly expressed in A549, 769-P, and Caco-2 cell lines and can exist as a soluble protein generated by metalloproteinase-mediated cleavage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.