Thermo Fisher Scientific KIM-1 Recombinant Rat Monoclonal Antibody (3B3)

Applications

Product Specifications

Product Specific Information

Specificity: This antibody is specific for murine TIM-1, a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family.

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 acts as a cellular receptor or co-receptor for several viruses, including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus.
Viral binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms within the human CD365 gene (HAVCR1) are associated with susceptibility and disease severity.
CD365 also plays a role in T cell co-stimulation and is primarily expressed in epithelial cells. It is highly expressed in A549, 769-P, and Caco-2 cell lines and can exist as a soluble protein generated by metalloproteinase-mediated cleavage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.