Thermo Fisher Scientific KIM-1 Chimeric Recombinant Rabbit Monoclonal Antibody (3B3)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Specificity:
This antibody is specific for murine TIM-1, a member of the T cell immunoglobulin domain, mucin-like domain (TIM) gene family.

Target Information

CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein consisting of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
The endogenous ligand for CD365 is Tim-4. CD365 functions as a cellular receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses. Viral binding occurs via phosphatidylserine exposed on viral envelopes.

Polymorphisms within the human CD365 gene (HAVCR1) are associated with susceptibility to infection and disease severity. CD365 is also implicated in T cell co-stimulation and is primarily expressed in epithelial cells. It is highly expressed in A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 can be generated by metalloproteinase-mediated proteolytic cleavage of the surface protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.