Thermo Fisher Scientific Human Lass6 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 13 amino acids near the amino terminus of human LASS6.
PEP-0768 can be used as a blocking peptide with polyclonal antibody PA5-20648.

Target Information

Longevity assurance genes (LAGs) represent a subgroup of the homeobox gene family. Five mammalian homologs have been reported, and the corresponding proteins have previously been investigated with respect to their key role in ceramide synthesis.
Members of the LAG family have been shown to be involved in cell growth regulation and cancer differentiation. LASS6 may be involved in sphingolipid synthesis or its regulation. It interacts with ATP6V0C, ASGR1, ASGR2, and SLC22A1/OCT1.
Localized to the nuclear membrane and possibly to the endoplasmic reticulum membrane. Glycosylation on Asn-18 is not necessary for function. Like other LAG family members, the LASS6 protein contains a homeodomain and LAG1 domain.
LASS6 displays highest homology to LASS5. The corresponding gene is localized to human chromosome 2q24.3, spanning a genomic region of approximately 318 kb.
Sequences in mouse and zebrafish suggest conservation of LASS6 in vertebrates due to high sequence homology. LASS6 is broadly expressed in a wide range of tissues and may play roles in cancer differentiation and early embryonic development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.