Thermo Fisher Scientific Human JPH4 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 17 amino acids near the center of human JPH4.
PEP-0766 can be used as a blocking peptide with polyclonal antibody PA5-20646.

Target Information

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.
Junctophilins (JPs) are important components of these junctional complexes. JPs consist of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a cytoplasmic domain that binds specifically to the PM.

Four JPs have been identified as tissue-specific subtypes:

• JPH1: Expressed in skeletal muscle
• JPH2: Detected throughout all muscle cell types
• JPH3, JPH4: Predominantly expressed in the brain

In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to subsurface cistern formation in neurons.
Mice lacking both JPH3 and JPH4 exhibit impaired learning and memory and abnormal nervous functions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.