Thermo Fisher Scientific Human JPH3 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 18 amino acids near the center of human JPH3.
PEP-0764 can be used as a blocking peptide with polyclonal antibody PA5-20644.

Target Information

Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels.
Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM.

Four JPs have been identified as tissue-specific subtypes derived from different genes:

• JPH1: expressed in skeletal muscle
• JPH2: detected throughout all muscle cell types
• JPH3 and JPH4: predominantly expressed in the brain

In the CNS, both JPH3 and JPH4 are expressed throughout neural sites and contribute to the subsurface cistern formation in neurons.
Mice lacking both JPH3 and JPH4 subtypes exhibit serious symptoms such as impaired learning and memory and are accompanied by abnormal nervous functions.
A repeat expansion in JPH3 is associated with Huntington disease-like 2.
At least two isoforms of JPH3 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.