Thermo Fisher Scientific Pan-cadherin Polyclonal Antibody
Pan-cadherin 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot, ICC/IF, ELISA, IP에 적합합니다. 인간, 마우스, 랫트, 개 시료에 반응하며, 액상 형태로 제공됩니다. 세포 간 칼슘 의존적 접착 연구에 유용합니다.
- 카탈로그번호
- PA5116886
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:10 |
| ELISA | 1 µg/mL |
| Immunoprecipitation (IP) | 0.5–4 µg antibody for 200–400 µg extracts |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 800–882 of human pan-cadherin (NP_004351.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.77 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901516 |
Product Specific Information
- Positive Samples: PC-3, A-431, Mouse brain, Rat brain
- Immunogen sequence:
RPANPDEIGN FIDENLKAAD TDPTAPPYDS LLVFDYEGSG SEAASLSSLN SSESDKDQDY DYLNEWGNRF KKLADMYGGG EDD
Target Information
Pan Cadherin (including CDH1, CDH2, CDH3, CDH4) belongs to a family of transmembrane molecules mediating calcium-dependent intercellular adhesion. Cadherins regulate morphogenetic movements and cell surface adhesion through homotypic interactions.
N-cadherin function depends on association with the actin cytoskeleton via catenin proteins, regulated by phosphorylation of beta-catenin.
This gene encodes a classical cadherin glycoprotein with five extracellular repeats, a transmembrane region, and a conserved cytoplasmic tail, essential for gastrulation and left-right asymmetry. It also mediates synaptic adhesion in the central nervous system.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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