Thermo Fisher Scientific ULK1/ULK2 Polyclonal Antibody
ULK1/ULK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 ELISA에 적합하며, 인간 시료 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 오토파지 관련 단백질 연구용.
- 카탈로그번호
- PA5116888
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 1–283 of human ULK1/ULK2 (NP_0035561) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901518 |
Product Specific Information
- Positive Samples: RD, SH-SY5Y, HepG2
- Immunogen sequence:
MEPGRGGTET VGKFEFSRKD LIGHGAFAVV FKGRHREKHD LEVAVKCINK KNLAKSQTLL GKEIKILKEL KHENIVALYD FQEMANSVYL VMEYCNGGDL ADYLHAMRTL SEDTIRLFLQ QIAGAMRLLH SKGIIHRDLK PQNILLSNPA GRRANPNSIR VKIADFGFAR YLQSNMMAAT LCGSPMYMAP EVIMSQHYDG KADLWSIGTI VYQCLTGKAP FQASSPQDLR LFYEKNKTLV PTIPRETSAP LRQLLLALLQ RNHKDRMDFD EFFHHPFLDA SPS
Target Information
Mammalian ULK1 (unc-51 like kinase 1) and ULK2, Caenorhabditis elegans UNC-51, and Drosophila melanogaster Atg1 are serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress.
ULK1 and ULK2 exhibit different tissue-specific expressions, contributing to diverse ULK-specific interaction networks.
ULK1 (or ULK2) interacts with several other proteins (ATG13, ATG101, RB1CC1/FIP200/ATG17) to form a complex required for autophagosome formation.
AMPK phosphorylates ULK1 at Ser317, Ser555, and Ser777 under low nutrient conditions.
mTOR phosphorylates ULK1 at Ser757, disrupting the interaction between ULK1 and AMPK.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-116888_ULK1ULK2_O75385-1_Rabbit.svg, PA5-116888_ULK1ULK2_Q8IYT8-1_Rabbit.svg, PA5-116888_ULK1ULK2_O75385-1_Rabbit_PDP.jpeg, PA5-116888_ULK1ULK2_Q8IYT8-1_Rabbit_PDP.jpeg)
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