Thermo Fisher Scientific CD85j (ILT2) Monoclonal Antibody (HP-F1), PE, eBioscience
CD85j(ILT2) 항원을 인식하는 HP-F1 클론의 PE 결합 단일클론 항체. 인간 시료에 반응하며 유세포분석(Flow Cytometry)에 최적화됨. 5 µL/test로 사용 가능하며, PBS 기반 완충액에 보관. 4°C 암소 보관, 동결 금지.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 5 µL (0.125 µg)/test
- Publications: View 6 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HP-F1 |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10804645 |
Available Formats
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 737
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Blue 610-70S
- NovaFluor Blue 660-120S
- NovaFluor Blue 690
- NovaFluor Red 700
- NovaFluor Red 725
- NovaFluor Yellow 570
- NovaFluor Yellow 590
- NovaFluor Yellow 610
- NovaFluor Yellow 660
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Request custom conjugation
Product Specific Information
The monoclonal antibody HP-F1 recognizes CD85j (ILT2, LILRB1, LIR1), a member of the ILT/LIR/MIR receptor family.
CD85j is a transmembrane glycoprotein with a cytoplasmic domain containing four ITIMs that signal via SHP-1. It is expressed on myeloid cells (monocytes, dendritic cells) and some lymphoid subsets (NK, T, B cells). Expression correlates with leukemias (ALL, CLL) and viral infections (HIV, EBV, CMV). Ligands include MHC Class I molecules (HLA-G, A, F, B27, E, F).
The HP-F1 antibody reduces CD16-dependent cytolytic activity of NK cells.
Applications Reported: Flow cytometry
Applications Tested: Pre-titrated; 5 µL (0.125 µg)/test for human peripheral blood cells (100 µL final volume).
Laser Compatibility: Blue, Green, Yellow-Green Lasers
Excitation / Emission: 488–561 nm / 578 nm
Filtration: 0.2 µm post-manufacturing filtered
Target Information
This gene belongs to the leukocyte immunoglobulin-like receptor (LIR) family located at chromosomal region 19q13.4.
It encodes a receptor with extracellular Ig domains, a transmembrane region, and cytoplasmic ITIM motifs that deliver inhibitory signals upon binding to MHC class I molecules.
These receptors regulate immune activation, control inflammation, and limit autoreactivity. Multiple transcript variants exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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