Thermo Fisher Scientific CD28 Monoclonal Antibody (CD28.2), PE

Applications

• Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
• View 2 publications

Product Specifications

Available Formats

• Unconjugated
• APC
• FITC
• PerCP
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa), which is a critical costimulatory receptor of T cells.

Target Information

CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein belonging to the immunoglobulin superfamily. It is constitutively expressed on most peripheral blood T lymphocytes and serves as a critical costimulatory receptor by binding CD80 and CD86 on antigen-presenting cells. CD28 prevents T cells from entering an anergic or apoptotic state, supporting full activation. In murine lymphoid tissues, CD28 is expressed on all CD4⁺ and CD8⁺ T cells, with varying expression levels across thymocyte maturation stages. Dysregulation of CD28 function is associated with diseases such as mycosis fungoides and Sezary's disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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