Thermo Fisher Scientific CD28 Monoclonal Antibody (CD28.2), PE
CD28 단백질을 인식하는 마우스 단클론 항체로, PE 형광 표지되어 Flow Cytometry 분석에 적합합니다. 인간 및 비인간 영장류 시료에 반응하며, T 세포 활성화 연구에 유용합니다. 4°C 보관, 동결 금지.
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Applications
- Flow Cytometry (Flow): 20 µL / 1×10⁶ cells
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD28.2 |
| Immunogen | DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA |
| Conjugate | PE |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152273 |
Available Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa), which is a critical costimulatory receptor of T cells.
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein belonging to the immunoglobulin superfamily. It is constitutively expressed on most peripheral blood T lymphocytes and serves as a critical costimulatory receptor by binding CD80 and CD86 on antigen-presenting cells. CD28 prevents T cells from entering an anergic or apoptotic state, supporting full activation. In murine lymphoid tissues, CD28 is expressed on all CD4⁺ and CD8⁺ T cells, with varying expression levels across thymocyte maturation stages. Dysregulation of CD28 function is associated with diseases such as mycosis fungoides and Sezary's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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