Thermo Fisher Scientific CD28 Monoclonal Antibody (CD28.2), FITC
인간 및 비인간 영장류 반응성 CD28 단클론 항체로, FITC 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 세포 활성화 및 T 세포 공동자극 연구에 활용되며, 안정한 액상 형태로 4°C 암소 보관이 필요합니다.
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Applications
- Flow Cytometry (Flow): 20 µL/1×10⁶ cells
- View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CD28.2 |
| Immunogen | DC28.1.3.3 murine T cell hybridoma transfected with human CD28 cDNA |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152348 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.
Target Information
CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell-specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 provides the essential second activation signal to T cells by binding CD80 and CD86 on antigen-presenting cells, preventing anergy and premature apoptosis.
In murine lymphoid organs, CD4⁺ and CD8⁺ T cells express CD28, with highest expression in immature thymocytes.
Diseases associated with CD28 dysfunction include mycosis fungoides and Sezary’s disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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