Thermo Fisher Scientific CD28 Monoclonal Antibody (CD28.2), PerCP

Applications

Flow Cytometry (Flow)

• Tested Dilution: 10 µL / 1×10⁶ cells

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular epitope of CD28, a disulfide-linked homodimeric type I glycoprotein (monomer of Mw 44 kDa) which is a critical costimulatory receptor of T cells.

Target Information

CD28 antigen is a 44 kDa disulfide-linked homodimeric T cell–specific surface glycoprotein. It belongs to the immunoglobulin superfamily and is constitutively expressed on most peripheral blood T lymphocytes. CD28 provides essential costimulatory signals for T cell activation by binding CD80 and CD86 on antigen-presenting cells. It also prevents T cells from entering an anergic or apoptotic state. In murine lymphoid organs, CD28 is expressed on all CD4+ and CD8+ T cells. Expression is highest on immature thymocytes and decreases upon maturation. CD28 dysfunction is associated with diseases such as mycosis fungoides and Sezary’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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