Thermo Fisher Scientific DNMT2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 192-391 of human TRDMT1 (NP_0044031) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Dnmt2,uniProtId:O14717-1,ncbiNodeId:9606,antigenRange:192-391,antigenLength:391,antigenImageFileName:PA5-87964_Dnmt2_O14717-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87964_Dnmt2_O14717-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.64 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804546

Product Specific Information

Immunogen sequence: VHPQKYAMDV ENKIQEKNVE PNISFDGSIQ CSGKDAILFK LETAEEIHRK NQQDSDLSVK MLKDFLEDDT DVNQYLLPPK SLLRYALLLD IVQPTCRRSV CFTKGYGSYI EGTGSVLQTA EDVQVENIYK SLTNLSQEEQ ITKLLILKLR YFTPKEIANL LGFPPEFGFP EKITVKQRYR LLGNSLNVHV VAKLIKILYE; Positive Samples: SKOV3, 293T, DU145, HeLa, H460; Cellular Location: Nucleus

Target Information

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a protein with similarity to DNA methyltransferases, but this protein does not display methyltransferase activity. The protein strongly binds DNA, suggesting that it may mark specific sequences in the genome. Alternative splicing results in multiple transcript variants encoding different isoforms.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.