Thermo Fisher Scientific FGFR1 Monoclonal Antibody (2F7)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family, consisting of four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity binding sites for 17 growth factors (FGF1–17). The FGF receptor family is crucial in various biological processes such as mesoderm induction, cell growth and migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, resulting in multiple variants expressed differently during embryonic development and in adult tissues.
Mutations or defects in FGFR1 are linked to several disorders, including:

• Pfeiffer syndrome (PS)
• Idiopathic hypogonadotropic hypogonadism (IHH)
• Kallmann syndrome type 2 (KAL2)
• Osteoglophonic dysplasia (OGD)
• Non-syndromic trigonocephaly
• Jackson-Weiss syndrome
• Antley-Bixler syndrome

Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia/lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.