Thermo Fisher Scientific FGFR1 Monoclonal Antibody (1B12)
FGFR1 단백질을 인식하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 1B12). Western blot과 ELISA에 사용 가능하며, Human 시료에 반응. 비결합형 액상 포맷으로 제공되며, -20°C에서 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B12 |
| Immunogen | FGFR1 (NP_075598.2, 303–408 a.a) partial recombinant protein with GST tag (MW of GST tag alone: 26 KDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Tissue culture supernatant |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family that includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family plays key roles in biological processes such as mesoderm induction, patterning, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed differently during embryonic development and in adults.
Defects in FGFR1 are associated with various diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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