Thermo Fisher Scientific FGFR1 Monoclonal Antibody (1B12)
FGFR1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot과 ELISA에 적합. 인간 시료에 반응하며, PBS(pH 7.4) 용액 형태로 제공. 보존제 무첨가, -20°C에서 보관 권장. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B12 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) belongs to the Fibroblast Growth Factor Receptor (FGFR) family, consisting of four membrane-spanning tyrosine kinases (FGFR1–4) that act as high-affinity receptors for 17 fibroblast growth factors (FGF1–17). These receptors are essential in mesoderm induction, cell growth, migration, organogenesis, and bone development.
FGFR1 undergoes alternative splicing, producing multiple isoforms with distinct expression patterns during embryogenesis and in adult tissues. Mutations or defects in FGFR1 are associated with diseases such as Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism (IHH), Kallmann syndrome type 2 (KAL2), osteoglophonic dysplasia (OGD), non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome. Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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