Thermo Fisher Scientific FGFR1 Monoclonal Antibody (3B2)
FGFR1 단백질을 인식하는 Mouse monoclonal antibody (Clone 3B2). Western blot 및 ELISA에 적합하며, 인간 시료에 반응. PBS 용액 내 보관, 보존제 없음. 연구용으로 세포 신호전달 및 성장 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3B2 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) belongs to the Fibroblast Growth Factor Receptor family (FGFR1–4), a group of membrane-spanning tyrosine kinases that act as high-affinity receptors for fibroblast growth factors (FGF1–17).
These receptors are involved in key biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, resulting in multiple isoforms expressed during embryonic and adult stages.
Mutations or chromosomal aberrations in FGFR1 are associated with several diseases, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal rearrangements involving FGFR1 are linked to stem cell myeloproliferative disorders and stem cell leukemia/lymphoma syndromes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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