Thermo Fisher Scientific FGFR1 Monoclonal Antibody (1E4)
FGFR1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 ELISA에 적합합니다. 인간 시료에서 반응하며, Affinity chromatography로 정제되었습니다. PBS buffer에 보관되며, -20°C에서 저장 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E4 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a.) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor (FGFR) family, which includes four membrane-spanning tyrosine kinases (FGFR1–4). These receptors serve as high-affinity receptors for 17 fibroblast growth factors (FGF1–17).
The FGFR family is involved in various biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone growth.
FGFR1 undergoes alternative splicing, producing multiple splice variants expressed differently during embryonic development and in adults.
Mutations or aberrations in FGFR1 are associated with several diseases, including Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, Kallmann syndrome type 2, osteoglophonic dysplasia, non-syndromic trigonocephaly, Jackson-Weiss syndrome, and Antley-Bixler syndrome.
Chromosomal aberrations involving FGFR1 are linked to stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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