Thermo Fisher Scientific PSD-95 Polyclonal Antibody
PSD-95 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 최적화되어 있으며 Mouse와 Rat에서 반응. 액상 형태로 제공되며, 고순도 친화 크로마토그래피 정제. 신경 시냅스 단백질 연구에 적합.
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminal region of rat DLG4 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2277305 |
Product Specific Information
This antibody is predicted to react with bovine, human, mouse, non-human primate, and zebrafish based on 100% sequence homology.
It is specific for the ~95 kDa PSD-95 protein.
Target Information
Post Synaptic Density 95 kDa (PSD-95), also known as synapse associated protein 90 kDa (SAP90), is a membrane-associated protein found in the postsynaptic density of forebrain neurons and certain presynaptic structures in the cerebellum.
PSD-95 contains three PDZ domains, an SH3 domain, and a Guanylate Kinase (GuK) domain.
It plays a key role in clustering NMDA receptors and Shaker-type potassium channels at the synaptic membrane in CNS neurons.
PSD-95 interacts with other proteins via two principal modes:
- Proteins with a C-terminal T/SXV motif (e.g., NMDA receptors, potassium channels, serotonin receptors).
- PDZ-PDZ interactions with proteins like neuronal nitric oxide synthase (nNOS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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