Thermo Fisher Scientific KV2.2 (KCNB2) Polyclonal Antibody
Thermo Fisher Scientific의 KV2.2 (KCNB2) 폴리클로날 항체는 Rat 및 Xenopus에 반응하며, 전기생리학적 연구에 적합합니다. Western blot 및 IHC에 사용 가능하며, 신경세포 막의 전압 의존성 K+ 채널 분석에 유용합니다. 고순도 친화 크로마토그래피로 정제된 항체로 안정적인 결과를 제공합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (IHC) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acid residues specific to the Kv2.2 subunit of rat KCNB2 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2131667 |
Product Specific Information
This antibody is specific for the ~125 kDa Kv2.2 protein.
Target Information
Kcnb2 (Kv2.2) encodes a voltage-gated K+ channel that plays a crucial role in neuronal membrane excitability. Differences in K+ channel expression and density influence action potential waveforms and repetitive firing patterns across neuronal cell types.
Delayed rectifier-type (IK) channels, including Kv1.5, Kv2.1, and Kv2.2, are found in neuronal somata, proximal dendrites, and various non-neuronal cells such as pancreatic islet, alveolar, and cardiac myocytes.
Kv2.1 and Kcnb2 form distinct K+ channel populations responsible for IK in superior cervical ganglion cells. Functionally, Kcnb2 mediates voltage-dependent potassium ion permeability of excitable membranes, enabling ion flow according to electrochemical gradients.
Diseases associated with KCNB2 include Brugada Syndrome.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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