Thermo Fisher Scientific TPH1 Polyclonal Antibody
TPH1 단백질을 인식하는 Thermo Fisher Scientific의 Sheep polyclonal 항체. Western blot 및 IHC에 적합하며, 인간, 토끼, 랫드 시료에 반응. 친화 크로마토그래피로 정제된 액상 형태로, -20°C에서 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | 1:1,000 | View 2 publications |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rabbit, Rat |
| Published Species | Rat |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant rabbit tryptophan hydroxylase, isolated as inclusion bodies from E. coli and purified by preparative SDS-PAGE |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561855 |
Product Specific Information
This antibody is predicted to react with a wide variety of mammals based on 100% sequence homology; however, it does not recognize TPH in rabbit tissues.
It specifically detects the ~55 kDa TPH protein in Western blots of human dorsal Raphe nucleus. Immunolabeling has been demonstrated in rat brain extracts.
Target Information
Tryptophan hydroxylase (TPH) catalyzes the 5-hydroxylation of tryptophan, the first step in the biosynthesis of indoleamines (serotonin and melatonin).
In mammals, serotonin biosynthesis occurs mainly in neurons of the Raphe nuclei, while melatonin synthesis occurs in the pineal gland.
TPH activity is rate-limiting for serotonin but not melatonin biosynthesis. Serotonin acts as a neurotransmitter, and melatonin is the principal hormone secreted by the pineal gland.
TPH activity is enhanced by phosphorylation via cAMP-dependent protein kinase (PKA) and Ca²⁺/calmodulin kinase II (CAM K II), both of which phosphorylate Ser58 within the regulatory domain of TPH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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