Thermo Fisher Scientific AMPD1 Polyclonal Antibody
Human AMPD1 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:50–1:200 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며 PBS/glycerol buffer에 보관. 근육 특이적 AMPD1 연구에 적합한 연구용 항체.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human AMPD1. Recombinant protein control fragment (Product # RP-94087) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2637916 |
Product Specific Information
- Immunogen sequence:
SETSSTKLSH IDEYISSSPT YQTVPDFQRV QITGDYASGV TVEDFEIVCK GLYRALCIRE KYMQKSFQRF PKTPSKYLRN IDGEAWVANE - Antigen sequence identity: Mouse - 92%, Rat - 92%
Target Information
AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia.
There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions, and capillaries.
This protein is the predominant member of the AMPD multi-gene family and acts as a sensor of the cell’s changing energy requirements. AMPD1 deficiency results in irregular muscle metabolism due to reduced ATP degradation, altered phosphocreatine hydrolysis, and lactic acid accumulation. Mutations in AMPD1 have been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies, and congestive heart failure associated with coronary artery disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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