Thermo Fisher Scientific AMPD1 Polyclonal Antibody

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200

Product Specifications

Product Specific Information

• Immunogen sequence:
  SETSSTKLSH IDEYISSSPT YQTVPDFQRV QITGDYASGV TVEDFEIVCK GLYRALCIRE KYMQKSFQRF PKTPSKYLRN IDGEAWVANE
• Antigen sequence identity: Mouse - 92%, Rat - 92%

Target Information

AMP deaminase (AMPD) is an allosteric enzyme involved in the regulation of adenosine metabolism. It catalyzes a central reaction in purine nucleotide biosynthesis where AMP is deaminated to IMP, liberating ammonia.
There are three functional isoforms of AMPD. AMPD1 (E.C. No 3.5.4.6.) is the skeletal muscle-specific isoform M located in type II muscle fibers, neuromuscular junctions, and capillaries.
This protein is the predominant member of the AMPD multi-gene family and acts as a sensor of the cell’s changing energy requirements. AMPD1 deficiency results in irregular muscle metabolism due to reduced ATP degradation, altered phosphocreatine hydrolysis, and lactic acid accumulation. Mutations in AMPD1 have been detected in neuromuscular disorders, exercise-induced skeletal muscle myopathies, and congestive heart failure associated with coronary artery disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.