Thermo Fisher Scientific NSE gamma (Neuron Specific Enolase, gamma) (Neuroendocrine Marker) Monoclonal Antibody (SPM347)

Applications and Tested Dilution

Product Specifications

Target Information

Neuron Specific Enolase (NSE, also known as ENO1, ENO2, ENO3 or enolase α, β, γ) is an enzyme involved in glycolysis and gluconeogenesis, catalyzing the conversion of 2-phosphoglycerate to phosphoenolpyruvate. NSE is highly stable in biological fluids and diffuses into extracellular media and cerebrospinal fluid (CSF) upon neuronal injury.

The γ-subunit (NSE gamma) is primarily expressed in neurons and neuroendocrine cells, both normal and neoplastic. Co-expression with chromogranin A is common in neuroendocrine neoplasms. Due to high energy demands, neurons are rich in glycolytic enzymes such as GAPDH and NSE.

Antibodies against NSE are valuable for identifying neuronal cell bodies, developing neuronal lineages, and neuroendocrine cells. NSE release from damaged neurons into CSF and blood serves as a biomarker for neuronal injury. Clinically, NSE is used as a sensitive marker for neuronal damage in conditions such as stroke, hypoxic brain injury, status epilepticus, Creutzfeldt-Jakob disease, and herpetic encephalitis. Elevated NSE levels are also associated with neoplasias including pediatric neuroblastoma and small cell lung cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.