Thermo Fisher Scientific Interleukin-1 beta (IL-1 beta) Monoclonal Antibody (IL1B/4650)
인간 IL-1β에 특이적인 마우스 단클론 항체로 염증 관련 연구에 적합. IHC, ELISA, Peptide Array 등 다양한 응용 가능. Protein A/G 정제, PBS 버퍼, 무보존제. -20°C에서 보관, 습식 얼음 배송.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1B/4650 |
| Immunogen | Recombinant fragment (around aa100–269) of human IL1B protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and requires inflammasome activation for cleavage into the active 17 kDa form. IL-1β lacks a signal sequence for classical secretion and is released via an alternate mechanism alongside caspase-1. It signals through IL-1RI and IL-1RII, shared with IL-1α, and its activity is regulated by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a crucial role in innate host defense and inflammation, with elevated levels linked to chronic inflammatory conditions. Neutralizing antibodies against IL-1β have potential therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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