Thermo Fisher Scientific Interleukin-1beta (IL-1beta) Monoclonal Antibody (IL1B/3993)
인간 IL-1β를 인식하는 단클론 항체로 염증성 사이토카인 연구에 적합합니다. IHC, ELISA, Peptide Array 등 다양한 응용 가능. 단백질 A/G로 정제된 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
| Peptide Array | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1B/3993 |
| Immunogen | Recombinant fragment of human IL1B protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as a 31 kDa inactive pro-form that accumulates in the cytosol and requires inflammasome activation for cleavage into the active 17 kDa form. IL-1β lacks a signal peptide for classical secretion and is released via an alternative mechanism alongside caspase-1. It signals through IL-1RI and IL-1RII receptors and its activity can be inhibited by IL-1 Receptor Antagonist (IL-1RA). IL-1β plays a key role in innate immune responses and is associated with chronic inflammatory conditions. Neutralizing antibodies against IL-1β may have therapeutic potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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