Thermo Fisher Scientific Interleukin-1beta (IL-1beta) Monoclonal Antibody (IL1B/6687)
인간 IL-1β를 인식하는 Mouse monoclonal antibody로, 염증 관련 연구에 적합합니다. IHC(P), IHC(PFA), ELISA 등 다양한 응용에 사용 가능하며, Protein A/G 정제, 보존제 무첨가 PBS 용액 형태입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1B/6687 |
| Immunogen | Recombinant fragment of human IL1B protein (exact sequence is proprietary) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Interleukin-1 beta (IL-1β) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is synthesized as an inactive 31 kDa precursor that requires cleavage by caspase-1 following inflammasome activation to produce the active 17 kDa form. IL-1β plays a critical role in innate immune responses by inducing other proinflammatory cytokines and initiating acute-phase reactions to infection and injury. Its activity is regulated by the IL-1 receptor antagonist (IL-1RA), which inhibits receptor binding. Elevated IL-1β levels are associated with chronic inflammatory diseases, and IL-1β neutralizing antibodies have potential therapeutic applications.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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