Thermo Fisher Scientific Interleukin-1 alpha (IL-1 alpha) Monoclonal Antibody (IL1A, 3981)
인간 IL-1α에 특이적인 mouse monoclonal antibody로 염증 및 면역 반응 연구에 적합. IHC(P)와 peptide array에 사용 가능. Recombinant fragment(aa 113-271)를 immunogen으로 하며, Protein A/G로 정제된 액상형 항체. -20°C 이하 보관.
- 카탈로그번호
- 3552-MSM1-P1ABX
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IL1A, 3981 |
| Immunogen | Recombinant fragment (around aa 113–271) of human IL1A protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 min.
Target Information
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. It is encoded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both shared with IL-1 beta.
Located on chromosome 2q13, IL-1 alpha plays a key role in innate host defense by inducing other proinflammatory cytokines and acute-phase responses.
Its activity is moderated by IL-1 Receptor Antagonist (IL-1RA), which blocks receptor binding through competitive inhibition.
IL-1 alpha regulates NF-kappaB and MAPK pathways, stimulates IL6 and COX-2 (PTGS2) expression, and enhances NO production.
High IL-1 alpha levels are linked to chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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