Thermo Fisher Scientific DNMT3B Monoclonal Antibody (4D1A2E5)
DNMT3B 단백질을 인식하는 Thermo Fisher Scientific의 마우스 단클론 항체로, WB, ICC/IF, Flow Cytometry, ELISA 등에 사용 가능. 인간에 반응하며 Protein G로 정제된 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 | – |
| Flow Cytometry (Flow) | 1:200–1:400 | – |
| ELISA | 1:10,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Gerbil |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4D1A2E5 |
| Immunogen | Purified recombinant fragment of human DNMT3B (aa: 1–150) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898424 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
CpG methylation is an epigenetic modification important for embryonic development, imprinting, and X-chromosome inactivation. DNA methylation is required for mammalian development. DNMT3B encodes a DNA methyltransferase functioning mainly in de novo methylation. The protein localizes primarily to the nucleus and is developmentally regulated. Mutations in this gene cause immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Six alternatively spliced transcript variants have been described; the full-length sequences of variants 4 and 5 have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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