Thermo Fisher Scientific EDA2R Monoclonal Antibody (4A6B4)
EDA2R 단백질을 인식하는 Mouse monoclonal 항체로, Western blot, Flow cytometry, ELISA 등에 적합합니다. Human 시료 반응성이 있으며, Protein G로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4A6B4 |
| Immunogen | Purified recombinant fragment of human EDA2R (aa: 1–138) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898426 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
X-linked ectodysplasin-A2 receptor (XEDAR) is a member of the tumor necrosis factor receptor family, highly expressed during embryonic development, and binds to ectodysplasin-A2 (EDA-A2). Two major isoforms, XEDAR-s and XEDAR-L, differ by a 21-amino-acid region at the juxtamembrane region of the cytoplasmic domain. Both isoforms lack a death domain and signal mainly through TRAF3 and TRAF6 to activate NF-κB and JNK pathways. Cells expressing XEDAR and treated with EDA-A2 form a complex containing FADD, caspase-8, and caspase-10, leading to activation of caspase-8 and caspase-3 and resulting in apoptosis. EDA-A2-induced apoptosis depends on caspase-9 activation, as inhibitors of caspase-8 block apoptosis following EDA-A2 treatment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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