Thermo Fisher Scientific AF9 Polyclonal Antibody
Thermo Fisher Scientific의 AF9 Polyclonal Antibody는 인간 AF9 단백질을 표적으로 하는 Rabbit IgG 항체입니다. IHC 및 IHC(Paraffin) 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C에서 보관하며 연구용으로만 사용됩니다.
- 카탈로그번호
- IHC00125x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific AF9 Polyclonal Antibody
Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 250 and 300 of human ALL1 Fused Gene from Chromosome 9 Protein (MLLT3, Myeloid/Lymphoid or Mixed-Lineage Leukemia Translocate 3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked gibbon, and Little brown bat.
Target Information
The human AF9 gene is one of the most common fusion partner genes with the ALL1 (MLL) gene at 11q23, resulting in the translocation t(9;11)(p22;q23).
AF9 spans more than 100 kb and contains two patient breakpoint cluster regions (BCRs):
- BCR1 within intron 4 (site A)
- BCR2 spanning introns 7 and 8 (site B)
Structural elements identified in AF9 include:
- In vivo DNA topo II cleavage site
- In vitro DNase I hypersensitive site in intron 7 (BCR2)
- Two scaffold-associated regions (SARs) centromeric to cleavage sites: SAR1 in intron 4 and SAR2 encompassing exons 5–7
These breakpoint regions share structural features with the MLL BCR.
A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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