Thermo Fisher Scientific CD103 (Integrin alpha E) Recombinant Rabbit Monoclonal Antibody (SN62-06)
CD103(Integrin alpha E)를 인식하는 재조합 토끼 단클론 항체로, IHC(P)에서 1:50–1:400 희석으로 사용 가능. HEK293 세포에서 발현되며 높은 특이성과 재현성을 제공. 단백질 A 정제, 1 mg/mL 농도, TBS buffer에 40% 글리세롤 포함. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:400 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN62-06 |
| Immunogen | Synthetic peptide within Human Integrin alpha E (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809564 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to rabbit immune repertoire
Target Information
CD103 (ITGAE, Integrin alpha E) is expressed on mucosa-associated T lymphocytes and activated cells, including a subset of TGFβ1-induced cells. It consists of a 150 kDa alpha chain and a 120 kDa beta chain. CD103 is expressed by 0.5–2% of resting lymphocytes in peripheral blood and lymphoid organs.
This molecule is part of the integrin family—heterodimeric integral membrane proteins composed of alpha and beta chains. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage, forming disulfide-linked heavy and light chains. In combination with beta 7 integrin, CD103 forms the E-cadherin-binding integrin known as the human mucosal lymphocyte-1 antigen.
CD103 is predominantly expressed in intestinal intraepithelial lymphocytes (IEL) and may serve as both an adhesion and accessory molecule for IEL activation. Dysregulation of CD103 is associated with diseases such as hairy cell leukemia and splenic marginal zone lymphoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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