Thermo Fisher Scientific Phospho-c-Myc (Thr58) Recombinant Rabbit Monoclonal Antibody (SN60-01)
Phospho-c-Myc (Thr58) 단백질을 검출하는 재조합 토끼 단클론 항체로, 높은 특이성과 민감도를 제공. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. HEK293 발현 시스템 기반으로 생산되어 로트 간 일관성 우수. 연구용 전용 제품.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SN60-01 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Thr58 of Human Myc (aa 30–79) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809561 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. These systems clone specific antibody DNA sequences from immunoreactive rabbits, followed by screening to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
The c-Myc protein is a 62 kDa transcription factor encoded by the c-Myc gene on human chromosome 8q24. It is commonly activated in various tumor cells and plays a key role in proliferation, differentiation, apoptosis, and cell cycle progression.
Phosphorylation at Thr58/Ser62 by kinases such as GSK3, CDK, ERK2, and JNK regulates cell proliferation and cycle control.
c-Myc is essential for vasculogenesis and angiogenesis in tumor development.
Amplification or translocation of the c-Myc gene is associated with multiple cancers, including lung, breast, colon, and Burkitt’s lymphoma.
Antibodies against c-Myc epitopes recognize overexpressed proteins containing Myc epitope tags fused to target proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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