Thermo Fisher Scientific DUSP2 Monoclonal Antibody (PAC-1), FITC
인간 CD41/CD61 복합체의 PAC-1 에피토프를 인식하는 FITC 표지 단일클론 항체입니다. Flow Cytometry에 적합하며, 혈소판 응집 관련 연구에 활용됩니다. 4°C 암소 보관하며, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): 4 µL / 1×10⁶ cells
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgM, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PAC-1 |
| Immunogen | Human platelets |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Purification | Size-exclusion chromatography |
| Storage Buffer | TBS, pH 8, with 0.2% BSA |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745523 |
Additional Formats
Product Specific Information
This antibody recognizes an extracellular activation-induced conformational epitope PAC-1 on the CD41/CD61 complex (gpIIb/IIIa), also known as integrin alpha IIb beta 3, a receptor mediating platelet aggregation.
Recommended dilution: 100 µL of whole blood or 1×10⁶ cells in suspension.
Target Information
The DUSP2 gene encodes a dual specificity protein phosphatase that inactivates its target kinases by dephosphorylating both phosphoserine/threonine and phosphotyrosine residues. These phosphatases negatively regulate MAP kinase family members (MAPK/ERK, SAPK/JNK, p38) involved in cellular proliferation and differentiation.
DUSP2 is predominantly expressed in hematopoietic tissues, localized in the nucleus, and primarily inactivates ERK1 and ERK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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