Thermo Fisher Scientific CCR5 Recombinant Superclonal Antibody (2HCLC)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This antibody is predicted to react with Monkey.
Recombinant rabbit Superclonal™ antibodies are unique offerings from Thermo Fisher Scientific. They combine multiple different recombinant monoclonal antibodies, providing the sensitivity of polyclonal antibodies with the specificity and consistency of monoclonal antibodies.
These antibodies recognize multiple epitope sites, ensuring higher detection sensitivity for low-abundance targets. Each lot contains a defined mixture of light and heavy chains, minimizing biological variability.
Note: Formerly called “Recombinant polyclonal antibody”, now rebranded as “Recombinant Superclonal™ antibody”. The product and performance remain unchanged.

Target Information

Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. CCR5 is a principal coreceptor for macrophage- and dual-tropic HIV-1 strains, facilitating fusion and entry of human white blood cells.
CCR5 is required for infection by HIV-1, HIV-2, and SIV. The beta-chemokines RANTES, MIP-alpha, and MIP-beta act as ligands for CCR5 and inhibit infection by M-tropic HIV-1.
CCR5 associates with the CD4-gp120 complex of HIV, leading to membrane fusion and viral entry. Its amino-terminal domain and extracellular loops serve as binding sites for HIV. CCR5 mRNA is expressed in lymphoid organs and monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.