Thermo Fisher Scientific Phospho-Chk1 (Ser345) Recombinant Rabbit Monoclonal Antibody (Chk1S345-R3F9)
Chk1 단백질의 Ser345 인산화 부위를 인식하는 재조합 토끼 단클론 항체로, 인간·마우스·랫트 시료에 반응합니다. 높은 특이성과 일관된 생산 품질을 제공하며, Flow Cytometry 등에 활용 가능합니다. 단백질 A/G 정제, PBS 저장, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Chk1S345-R3F9 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser345 of human phospho Chk1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745001 |
Available Conjugated Formats
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Key advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the large rabbit immune repertoire
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase that plays a critical role in maintaining genomic integrity when DNA damage occurs. It mediates DNA damage-induced checkpoint control and prevents replication under compromised DNA conditions.
Inhibition of CHK1 can induce mitotic catastrophe in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment, particularly since about 50% of human cancers lack functional p53.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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