Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI1F1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IDO1 (Indoleamine 2,3-dioxygenase 1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring in molecules such as tryptophan, serotonin, and melatonin, leading to the formation of kynurenines.
It is widely expressed in human tissues, macrophages, and dendritic cells.
IDO1 expression is induced by interferons (IFNs) and contributes to antimicrobial defense by degrading tryptophan, thereby inhibiting the growth of viruses, bacteria, and parasites.
Additionally, IDO1 plays a crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.