Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI3B10), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:4,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:100

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of tryptophan, serotonin, and melatonin. This process leads to the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by depleting tryptophan and inhibiting pathogen growth.
Additionally, IDO1 plays a crucial role in immune regulation during infection, pregnancy, autoimmunity, transplantation, and tumor development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.