Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI3B10), TrueMAB
IDO1 단백질을 인식하는 Mouse monoclonal 항체로, Human 시료에 반응합니다. Western blot 및 Immunocytochemistry에 사용 가능하며, 동결건조 형태로 제공됩니다. PBS buffer에 trehalose 포함, -20°C 보관 권장.
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Applications
Western Blot (WB)
- Tested Dilution: 1:4,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3B10 |
| Immunogen | Full length human recombinant protein of human IDO1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to reach a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform additional desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of tryptophan, serotonin, and melatonin. This process leads to the production of biologically active metabolites known as kynurenines.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. During inflammation, interferons (IFNs) induce IDO1 expression, contributing to antimicrobial defense by depleting tryptophan and inhibiting pathogen growth.
Additionally, IDO1 plays a crucial role in immune regulation during infection, pregnancy, autoimmunity, transplantation, and tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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