Thermo Fisher Scientific IDO1 Monoclonal Antibody (OTI4C11), TrueMAB
IDO1 단백질을 인식하는 Mouse monoclonal antibody로, Western blot과 Immunocytochemistry에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. 고순도의 Affinity chromatography 정제 제품으로 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:4,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C11 |
| Immunogen | Full length human recombinant protein of human IDO1 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IDO1 (Indoleamine 2,3-dioxygenase 1) is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of tryptophan, serotonin, and melatonin. This reaction initiates the formation of kynurenines, biologically active metabolites involved in immune regulation.
IDO1 is expressed in various human tissues, macrophages, and dendritic cells. Its expression is induced by interferons (IFNs), contributing to antimicrobial mechanisms by depleting tryptophan and inhibiting pathogen growth.
Additionally, IDO1 plays a critical role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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