Thermo Fisher Scientific ALPP Monoclonal Antibody (OTI1H2), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution

• 1:200–1:1,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Placental Alkaline Phosphatase (PLAP) plays a key role in regulating inflammatory disease processes. There are four related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney.
PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) present in the placenta during the third trimester. It is useful for identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors express epithelial membrane antigen (EMA).
A proposed function of PLAP is matrix mineralization; however, mice lacking this enzyme show normal skeletal development. PLAP has been associated with hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity and onset vary depending on the specific mutation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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