Thermo Fisher Scientific TGM2 Monoclonal Antibody (14G2)

Applications and Tested Dilution

Product Specifications

Product Specific Information

A suggested positive control for this product is U87-MG cells.

Target Information

Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity. In mammals, eight distinct TGase isoenzymes have been identified.
Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis.
In Alzheimer’s disease, elevated tTGase activity is associated with polymerization of several proteins, including Aβ peptide, β-amyloid precursor protein, and tau protein, leading to neurofibrillary tangle formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.