Thermo Fisher Scientific TGM2 Monoclonal Antibody (2A1)
TGM2 단백질을 인식하는 Mouse monoclonal 항체로 Western blot, ICC/IF, ELISA, IP 등 다양한 응용에 적합. 인간 transglutaminase 2를 면역원으로 제작되었으며 1 mg/mL 농도의 액상 형태로 제공. 연구용으로 세포 사멸, 분화 관련 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 2 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 5 µg |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2A1 |
| Immunogen | Purified, recombinant, human transglutaminase 2 protein expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_1088040 |
Product Specific Information
A suggested positive control for this product is U87-MG cells.
Target Information
Transglutaminase (TGase) catalyzes the crosslinking of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires Ca²⁺ binding for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, consists of four distinct domains: N-terminal β-sandwich, catalytic core, and two C-terminal β-barrel domains.
tTGase may play roles in cell death, proliferation, differentiation, and receptor-mediated endocytosis. In Alzheimer's disease, elevated tTGase activity is associated with polymerization of proteins such as Aβ peptide, β-amyloid precursor protein, and tau, leading to neurofibrillary tangle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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