Thermo Fisher Scientific GPX1 Monoclonal Antibody (42C9)

Applications

Immunoprecipitation (IP)

• Tested Dilution: 1 µL

Product Specifications

Product Specific Information

A suggested positive control for this product is HL-60 cells.

Target Information

Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins that catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione.
There are several isoforms which differ in their primary structure and localization.
The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, the first of the GPx family to be discovered.
GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract.
Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney, from where it is released into the blood circulation.
Phospholipid hydroperoxide GPx4 (PH-GPx), expressed in most tissues, can reduce many hydroperoxides including those integrated in membranes or lipoproteins.
All mammalian GPx family members, except for the recently described Cys-containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.