Thermo Fisher Scientific IL-29 Polyclonal Antibody
Human IL-29 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot과 ELISA에 적합합니다. 고순도 IgG 분획으로 제조되었으며, 항바이러스 관련 연구에 활용 가능합니다. 동결건조 형태로 제공되며 장기보관 시 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This IgG fraction antibody was prepared from rabbit antiserum after repeated immunizations with mature length recombinant human IL-29 protein produced in E. coli. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at 4°C prior to restoration. For extended storage, aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Anti-IL-29 is an IgG fraction antibody purified from monospecific antiserum by a multi-step process including delipidation, salt fractionation, and ion-exchange chromatography followed by extensive dialysis against the specified buffer. This antibody is specific for human IL-29 protein. A BLAST analysis suggests cross-reactivity with IL-29 from human sources based on 100% homology with the immunizing sequence. Based on high to 100% homology, there is a possibility of cross-reactivity with IL-29 from other species, though this has not been experimentally confirmed.
Target Information
IFN-lambdas constitute a novel family of interferons that mediate anti-viral protection across various cell types. This family includes three members: lambda1 (IL-29), lambda2 (IL-28A), and lambda3 (IL-28B). Similar to type I interferons, IFN-lambdas activate intracellular signaling to induce gene expression. They function through a class II cytokine receptor complex composed of CRF2-12/IFN-lambdaR1 (unique to IFN-lambdas) and CFR2-4/IL-10R2 (shared with IL-10, IL-22, and IL-26 receptors).
IL-28 and IL-29 have been reported to prime dendritic cells to induce proliferation of Foxp3-bearing regulatory T cells. Dendritic cells differentiated in response to IFN-lambdas express high levels of class I and II MHC molecules but low levels of costimulatory molecules, and can induce IL-2-dependent proliferation of CD4+CD25+FOXP3+ T cells with contact-dependent suppressive activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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