Thermo Fisher Scientific IL-22 Polyclonal Antibody
Human IL-22 단백질에 특이적인 Rabbit Polyclonal Antibody로, Western blot 및 ELISA에 최적화되어 있습니다. 고순도의 IgG 분획 항체이며, -20°C에서 안정적으로 보관 가능합니다. 연구용으로만 사용됩니다.
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카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific IL-22 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1:20,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Anti-IL-22 antibody was prepared from rabbit antiserum after repeated immunizations with a truncated form of recombinant human IL-22 protein from E. coli. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Ion-exchange chromatography |
| Storage Buffer | 0.02 M potassium phosphate, pH 7.2, with 0.15 M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid freeze–thaw cycles. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
Anti-IL-22 is an IgG fraction antibody purified from monospecific antiserum by a multi-step process including delipidation, salt fractionation, and ion-exchange chromatography, followed by extensive dialysis against the specified buffer. This antibody is specific for human IL-22 protein. A BLAST analysis suggests cross-reactivity with IL-22 from human sources based on 100% homology with the immunizing sequence. Cross-reactivity with IL-22 from other species has not been determined.
Target Information
IL-22, also known as IL-10-related T-cell derived inducible factor, is an alpha-helical cytokine belonging to the IFN-IL-10 family, which includes IL-19, IL-20, IL-24, IL-26, IL-28, IL-29, and type I and II interferons. IL-22 is mainly produced by activated T cells and NK cells. In humans, the IL-22 gene is located on chromosome 12q and is structurally related to IL-10.
IL-22 acts through a heterodimeric receptor complex consisting of IL-22R1 and IL-10R2. IL-22R1 also binds IL-20 and IL-24, while IL-10R2 binds IL-10, IL-27, IL-28, and IL-29. Binding of IL-22 to its receptor induces JAK-STAT signaling. A soluble receptor, IL-22BP, can antagonize IL-22 binding and signaling.
IL-22 primarily targets nonimmune cells such as keratinocytes, hepatocytes, and epithelial cells of the skin, digestive, and respiratory systems. It functions as an effector cytokine of the Th17 lineage and, along with IL-17A and IL-17F, regulates genes involved in innate skin immunity. IL-22 promotes wound healing, induces antimicrobial proteins, and is critical for defense against extracellular pathogens. It is upregulated during chronic inflammation and activates intracellular kinases and transcription factors, including STAT3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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